Journal
MACROMOLECULAR BIOSCIENCE
Volume 9, Issue 12, Pages 1165-1168Publisher
WILEY-BLACKWELL
DOI: 10.1002/mabi.200900221
Keywords
biocompatibility; 2-hydroxyethyl methacrylate (HEMA); N-isopropyl acrylamide (NIPAAm); polyurethanes; proteins
Funding
- National Natural Science Foundation of China [20634030]
- Ministry of Science and Technology of China [2008CB617510]
- Hubei Province Natural Science Foundation of China [2008CDB270]
- Program for New Century Excellent Talents in University [NCET0606055]
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In this communication, we introduce a facile and highly efficient approach for surface modification of polyurethane (PU). Double bonds were incorporated onto the PU surface using a unique monomer, methacryloyl isothiocyanate (MI). Several monomers, such as N-isopropyl acrylamide (NIPAAm) and 2-hydroxyethyl methacrylate (HEMA), were used to prove that the polymerization process can be carried out on a vinyl-functionalized surface. The protein-adsorption property of the grafted surfaces shows that protein adsorption was significantly reduced after grafting each polymer onto the PU surface. Moreover, this method can be applied to polyurethane materials with any shape, including tubes and scaffolds, for which plasma treatment and photoinitiation at the inner surface are difficult to perform.
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