Journal
MACROMOLECULAR BIOSCIENCE
Volume 9, Issue 1, Pages 36-44Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.200800193
Keywords
diblock copolymers; conjugated polymers; reversible addition fragmentation chain transfer (RAFT); self-assembly; HPMA; beta-sheet peptide
Funding
- NIH [EB 005288]
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The self-assembly of hybrid diblock copolymers composed of poly(HPMA) and P-sheet peptide P11 (CH3CO-QQRFQWQFEQQ-NH2) blocks was investigated. Copolymers were synthesized via thiol-maleimide coupling reaction, by conjugation of semitelechelic poly(HPMA)-SH with maleimide-modified beta-sheet peptide. As expected, CD and CR binding studies showed that the peptide block imposed its beta-sheet structural arrangement on the structure of diblock copolymers. TEM and AFM proved that peptide and these copolymers had the ability to self-assemble into fibrils.
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