Journal
MACROMOLECULAR BIOSCIENCE
Volume 9, Issue 7, Pages 646-653Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.200900009
Keywords
dynamic light scattering; fluorescence recovery after photobleaching; hyaluronic acid; hydrogels; molecular dynamics
Funding
- MIUR
- (CASPUR) of Rome
- PRIN 2007 fund
- FIDIA
Ask authors/readers for more resources
Hyaluronic acid is a polysaccharide with viscoelastic and mechanical properties that are crucial for the normal functioning of osteoarticular junctions. It is demonstrated that introduction of a hexadecyl side chain into HA yields an injectable polysaccharide capable of forming physical hydrogels, which are stable at very low polymer concentrations, whereas native hyaluronic acid forms viscous solutions at concentrations that are ten times higher. Characterization of this system showed that the driving force for its gel-like behavior is the occurrence of hydrophobic interactions involving aliphatic side chains, despite the low degree of substitution, as confirmed by molecular dynamics simulations of HYADD4 and HA hydrogels.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available