Journal
MACROMOLECULAR BIOSCIENCE
Volume 9, Issue 11, Pages 1090-1097Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.200900110
Keywords
differential scanning calorimetry (DSC); drug delivery systems; glass transition; hyperbranched; synthesis
Funding
- National Basic Research Program [2007CB808000, 2009CB930400]
- National Natural Science Foundation of China [50873058, 20874060, 50633010]
- Shanghai Leading Academic Discipline [13202]
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This work is focused on the controlled drug release behavior of hyperbranched HPMA in the presence of beta-CD. Hence, three HPMA-beta-CDs and a pure HPMA were synthesized by Michael addition polymerization. As a model drug, CLB (an anti-cancer drug) was loaded into them via a solution method for in vitro release studies. The DSC results indicate that the CLB/polymer interactions are at the molecular level. Loading CLB into these polymers results in an evident increase in their glass transition temperatures, and Delta T-g depends on the beta-CD content. The controlled-release experiments show that the presence of beta-CD can appropriately slow the release of CLB from HPMA-beta-CDs and adjust the ratio of CLB released in total drug loading.
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