Journal
MACROMOLECULAR BIOSCIENCE
Volume 9, Issue 5, Pages 429-436Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.200800381
Keywords
cancer therapy; drug delivery systems; 2-methoxyestradiol; polyelectrolyte multilayers; self-assembly
Funding
- National CancerInstitute (NCI)
- National Institutes of Health [NOI-CO-97111, R01 A137141, P60DK20572]
- Shanghai Institutions of Higher Learning.
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Development of a novel formulation of anticancer drugs to improve their water-solubility and biclavailability remains a great challenge. Herein, the potential anticancer agent 2-methoxyestradiol (2-ME) was selected as a model drug and was encapsulated within polyelectrolyte (PE) multilayers by layer-by-layer deposition of oppo-IrE sitely charged PEs onto the drug microcrystal surtwo cell lines reveal that the PE multilayer-encapsulated 2-ME microcrystals markedly decrease the cell viability, displaying similar inhibitory effect to that of the conventional formulation of 2-ME dissolved in ethanol. The current approach to encapsulate hydrophobic drug microparticles may be useful for formulating different drugs for a variety of biological applications.
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