Journal
MACROMOLECULAR BIOSCIENCE
Volume 9, Issue 10, Pages 952-958Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.200900154
Keywords
cell sorting; fluorescent detection; magnetic separation; multifunctional platform; nanocrystals; nanostructures
Funding
- Italian Ministry of Research under FIRB [RBN01KJHT-007, RBIN048TSE]
- Italian Institute of Technology
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Nanostructures displaying fluorescence and magnetic properties at the same time are potentially useful for achieving simultaneous bio-separation and bio-sensing (e.g., magnetic separation coupled with multiplexing optical detection of different tumour cell populations). Spherical nanobeads that display both fluorescent and magnetic features are reported; they are fabricated by grafting fluorescent oligothiophene molecules to an amphiphilic polymer that is then used to enwrap iron oxide nanoparticles, which acts as the magnetic domain. By tuning experimental conditions, control over the number of magnetic nanoparticles per bead and over the bead diameter (30-400 nm) was achieved. A cell separation efficiency of the level required for cell sorting applications is also reported.
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