Journal
MACROMOLECULAR BIOSCIENCE
Volume 9, Issue 2, Pages 140-156Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.200800284
Keywords
drug delivery; extracellular matrix; heparin; hyaluronic acid; hybrid hydrogels; microgels; networks; polysaccharide particles; tissue engineering
Funding
- National Institutes of Health [R01 DC008965, 1 R01 EB00317201]
- National Science Foundation [DMR-0643226, DBE-0221651]
- Arnold and Mabel Beckman Foundation
Ask authors/readers for more resources
Artificial ECMs that not only closely mimic the hybrid nature of the natural ECM but also provide tunable material properties and enhanced biological functions are attractive candidates for tissue engineering applications. This review summarizes recent advances in developing multicomponent hybrid hydrogels by integrating modular and heterogeneous building blocks into well-defined, multifunctional hydrogel composites. The individual building blocks can be chemically, morphologically, and functionally diverse, and the hybridization can occur at molecular level or microscopic scale. The modular nature of the designs, combined with the potential synergistic effects of the hybrid systems, has resulted in novel hydrogel matrices with robust structure and defined functions.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available