Journal
MACROMOLECULAR BIOSCIENCE
Volume 9, Issue 7, Pages 694-701Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.200800288
Keywords
chaperon-like activity; dendrimers; highly branched cyclic dextrin; nanogel; protein delivery; self-assembly
Funding
- Ministry ofEducation, Culture, Sports, Science Technology
- CREST
- JST
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Highly branched cyclic dextrin derivatives (CH-CDex) that are partly substituted with cholesterol groups have been synthesized. The CH-CDex forms monodisperse and stable nanogels with a hydrodynamic radii of approximate to 10 nm by the self-assembly of 4-6 CH-CDex macromolecules in water. The CH-CDex nanogels spontaneously trap 10-16 molecules of fluorescein isothiocyanate-labeled insulin (FITC-Ins). The complex shows high colloidal stability: no dissociation of trapped insulin is observed after at least 1 month in phosphate buffer (0.1 M, pH 8.0). In the presence of bovine serum albumin (BSA, 50 mg center dot mL(-1)), which is a model blood system, the FITC-Ins trapped in the nanogels is continuously released (approximate to 20% at 12 h) without burst release. The high-density nanogel structure derived from the highly branched CDex significantly affects the stability of the nanogel-protein complex.
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