Journal
MACROMOLECULAR BIOSCIENCE
Volume 8, Issue 11, Pages 1053-1059Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.200800180
Keywords
bolaamphiphilic; nanostructure; peptide; self-assembly; stability
Funding
- Ministry of Education of the People's Republic of China
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A new self-assembling bolaamphiphilic peptide has been designed and synthesized using only natural amino acids. This simple peptide is composed of two lysines connected by 4-8 alanines to maintain the characteristics of the traditional bolaamphiphiles. Based on an irregular secondary structure, it can self-assemble into nanospheres, nanorods, or nanofibers with lengths up to micrometers. The long nanofibers can be broken into smaller fragments by sonication, however, they could reassemble into nanofibers after incubation. Furthermore, the nanostructures were shown to have considerable thermostability. This new bolaamphiphilic peptide differs from any other self-assembling peptides or bolaamphiphiles, and possibly provides a new approach to fabricate nanomaterials.
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