Journal
MACROMOLECULAR BIOSCIENCE
Volume 8, Issue 10, Pages 942-950Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.200800007
Keywords
biocompatibility; crosslinking; gelatin; oligomeric proanthocyanidins; tricalcium phosphate
Funding
- National Science Council of the Republic of China, Taiwan [NSC96-2628-E-166-008-MY3]
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A biodegradable GTP composite composed of OPCs crosslinked gelatin with tricalcium phosphate was prepared as a novel bone substitute. The effects of the degree of crosslinking on the swelling ratio, in vitro degradation rate, and morphology of the GTP composite are discussed. Adding OPCs to GP and GTP composites markedly reduced the degradation rate, indicating 1 P. that OPCs are good crosslinking reagents for gelatin. Cytotoxic tests demonstrated that OPCs, gelatin and tricalcium phosphate released from GTP composite promoted the proliferation of MG-63 cells. Results of this study suggest that the nontoxic GTP composite is suitable for use as a large defect bone substitute.
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