Loading and in vitro controlled release of indomethacin using amphiphilic cholesteryl-bearing carboxymethylcellulose derivatives

Amphiphilic CCMCs were synthesized under mild conditions and their chemical structures were characterized by FT-Ill, and (1)H NMR spectroscopy. Fluorescence analysis showed that CCMCs could self-associate to form polymeric micelles in aqueous solution. IND was encapsulated during the formation of CCMC micelles and its in vitro release properties were investigated The loading capacity was more than 50% and the loaded IND was slowly and steadily released into the medium over a period of 8 h. The CCMC micelles showed pH-responsive behavior during the drug-loading and release processes. CCMC is promising as a potential delivery system for the controlled release of IND with a pH-responsive property.