Journal
MACROMOLECULAR BIOSCIENCE
Volume 8, Issue 8, Pages 758-765Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.200700316
Keywords
biopolymers; crosslinking; drug delivery systems; microencapsulation
Funding
- U.S. Department of Energy [DEFG02-91-ER45439]
- Korean Ministry of Commerce, Industry and Energy [10024816]
- Linda Sah
- Korea Institute of Industrial Technology(KITECH) [10024816] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Uniform gelatin microspheres (GMS) of a wet size of 100 mu m in diameter were fabricated by the electric field assisted precision particle fabrication (E-PPF) method and crosslinked with different glutaraldehyde (GA) concentrations to study the effect of the crosslinking density on drug release. The drug release profiles of the crosslinked GMS were studied along with the intraparticle drug distribution and the particle degradation characteristics. Due to the concentration gradient of GA along the diffusion path into the GMS, the crosslinking density is higher on the GMS surface, making it less susceptible to degradation. As a result, the GMS with higher GA concentrations (0.375-0.875%) exhibited a highly resistant surface toward enzymatic degradation. On the other hand, the amount of drug complexation at the surface decreases as the GA concentration increases, which can be attributed to the lowered basicity of gelatin caused by the increased crosslinking density. These factors collectively affect the drug release kinetics and give rise to similar release profiles for GMS above a GA concentration of 0.375%.
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