Journal
MABS
Volume 4, Issue 6, Pages 784-787Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/mabs.22287
Keywords
receptors for the Fc portion of IgG; immune thrombocytopenic purpura; linkage disequilibrium
Categories
Funding
- Institut National du Cancer and Canceropole Grand Ouest (Mab Impact)
- Fondation Langlois
- Region Centre
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The FCGR3A-V158F and FCGR2A-H131R polymorphisms are associated with clinical responses to therapeutic mAbs and with immune thrombocytopenic purpura (ITP). The FCGR2C-ORF/STOP polymorphism, controlling Fc gamma RIIC expression on natural killer cells and therefore Fc gamma RIIC-mediated antibody dependent cell-mediated cytotoxicity, is also associated with ITP. Using a new pyrosequencing assay to determine this polymorphism in a control population, we observed the expected allele frequencies (ORF:12.6%) and percentages of individuals with a single copy (10.0%) or 3 copies (12.1%) of FCGR2C, or with at least one FCGR2C-OR F allele (20.1%). No association of FCGR2C copy number variations with the FCGR3A-V158F or FCGR2A-H131R genotype was detected. More importantly, our results demonstrate a strong and a weaker linkage disequilibrium associating the FCGR2C-ORF allele with the FCGR3A-158V and the FCGR2A-131H allele, respectively.
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