Journal
LWT-FOOD SCIENCE AND TECHNOLOGY
Volume 46, Issue 1, Pages 164-168Publisher
ELSEVIER
DOI: 10.1016/j.lwt.2011.10.011
Keywords
Anti-diabetes; alpha-Glucosidase; Pancreatic lipase; Phenolic compounds; HPLC-MS
Categories
Funding
- Department of Defense [W911QY-07-C-0033]
- National Natural Science Foundation of China [30928017]
- Chinese CAS/SAFEA
Ask authors/readers for more resources
Inhibitory mode mode and anti-diabetic activities of the Carols muscadine extracts on the alpha-glucosidase and pancreatic lipase were investigated. The IC50 values of the muscadine and its seed methanolic extracts against the alpha-glucosidase were 1.92 and 1.53 mg/mL, and those against the lipase were 34.41 and 8.63 mg/mL, respectively, which indicated the muscadine possessed the strong anti-diabetes activity. Particularly, the ethyl acetate (EtOAc) extract fractions exhibited the highest inhibitory activities against both enzymes. Since most of the phenolic compounds existed in the EtOAc fractions, it is suggested that phenolic compounds may be the main source against the alpha-glucosidase and pancreatic lipase. Twelve individual phenolics were identified by HPLC-MS. Ellagic acid and quercetin exhibited much stronger anti-diabetic activities among the selected phenolic standards. Besides, the extracts and the phenolic standards obeyed the competitive mode in their enzymatic inhibitions. Published by Elsevier Ltd.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available