Journal
LUPUS
Volume 21, Issue 7, Pages 790-792Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/0961203312444173
Keywords
antiprothrombin antibodies; phosphatidylserine-dependent antiprothrombin antibodies; avidity; enzyme immunoassays; antiphospholipid syndrome
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Funding
- Ministry of High Education, Science and Technology of Slovenia [P3 0314]
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Antiprothrombin antibodies can be measured by ELISA using either a prothrombin/phosphatidylserine complex (aPS/PT) or prothrombin alone (aPT) as antigen. We aimed to compare the clinical features of autoimmune patients with avidity of aPS/PT and determine the diagnostic efficiency of aPS/PT and aPT for assessing antiphospholipid syndrome (APS). aPS/PT were of low (n = 9), heterogeneous (n = 31) and high (n = 8) avidity out of 48 cases. None of the samples with low avidity were positive in aPT ELISA. Among patients with heterogeneous or high avidity aPS/PT, there was a significantly greater number of patients with APS as compared to patients with low avidity (38/39 vs. 7/9; p < 0.05). No SLE patients had high avidity antiprothrombin antibodies. Lupus (2012) 21, 790-792.
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