Journal
LUPUS
Volume 19, Issue 4, Pages 389-393Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/0961203309360542
Keywords
antiphospholipid serum; GPIb; LDL receptor
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One of the greatest enigmas in thrombosis research is the observation that one can diagnose a person with a thrombotic risk with a prolongation of the clotting time. Our textbooks have taught us that prolongation of clotting correlates with a tendency to bleed. To confuse our textbook knowledge further, the same patients often have a prolonged bleeding time, a diagnostic test to detect a dysfunction in primary haemostasis. In this paper we critically review the literature that tries to explain the contradiction that exists between in-vitro diagnostic tests and the observed clinical manifestations and discuss our current opinion on how antiphospholipid antibodies can disturb the haemostatic balance. Lupus (2010) 19, 389-393.
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