Journal
LUPUS
Volume 17, Issue 3, Pages 177-184Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/0961203307086639
Keywords
seizures; lupus; PROFILE
Categories
Funding
- NCRR NIH HHS [M01-RR02558, M01-RR00048, M01 RR000032, UL1 RR025741, M01 RR002558, M01 RR000048, 1P20-RR11126, M01 RR000052, M01 RR000048-410373, M01-RR00052, M01-RR00032, P20 RR011126] Funding Source: Medline
- NIAMS NIH HHS [AR43727, R01 AR043727, R01 AR033062, K24 AR002138, P60 AR048098, P60AR048098, P01 AR049084-01, K24-AR002138, P60 AR048098-01, P01AR49084, K24 AR002138-07, P01 AR049084] Funding Source: Medline
- NATIONAL CENTER FOR RESEARCH RESOURCES [M01RR002558, P20RR011126, UL1RR025741, M01RR000048, M01RR000052, M01RR000032] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R01AR033062, P01AR049084, K24AR002138, R55AR043727, P60AR048098, R01AR043727] Funding Source: NIH RePORTER
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The objective of this study was to determine risk factors predicting seizures and damage caused by seizures in a multi-ethnic systemic lupus erythematosus cohort (PROFILE) that includes systemic lupus erythematosus patients (n = 1295) from five different US institutions. Only patients with seizures after systemic lupus erythematosus diagnosis (incident) were included in the analyses of clinical seizures (80/1295, 6.2%), but all patients (prevalent and incident) were included in the analyses of damage caused by seizures (51/1295, 3.9%). We examined socioeconomic-demographic, clinical, and genetic variables predictive of clinical seizures and damage from seizures by Cox proportional hazard ratios (HR) and 95% confidence intervals (Q. Independent predictors of a shorter time to the occurrence of clinical seizures were younger age (HR = 1.0; 95% CI 0.9-1.0), having Hispanic-Texan ethnicity (FIR = 2.7; 95% CI 1.3-5.7) or African-American ethnicity (HR = 1.8; 95% CI 1.0-3.1), and the previous occurrence of a cerebrovascular accident (FIR = 3.3; 95% CI 1.6-7.1) or an episode of psychosis (FIR = 2.4; 95% CI 1.1-5.0), whereas the previous occurrence of photosensitivity (HR = 0.5; 95% CI 0.3-0.9) was the only independent predictor of a longer time to the occurrence of clinical seizures. Independent predictors of a shorter time to the occurrence of damage caused by seizures were younger age (HR = 1.0; 95% CI 0.9-1.0), male gender (HR = 2.4; 95% CI 1.1-5.4), and the occurrence of a previous cerebrovascular accident (FIR = 2.7; 95% CI 1.0-7.0) or an episode of psychosis (FIR = 4.7; 95% CI 2.3-9.9). No allele from the candidate genes examined (HLA-DRB1, HLA-DQB1, FCGR2A, FCGR3A, or FCG3B) predicted clinical seizures or damage caused by seizures.
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