Journal
LUNG CANCER
Volume 76, Issue 3, Pages 493-495Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.lungcan.2012.02.014
Keywords
Eosinophilia; GM-CSF; Lung cancer; Large-cell carcinoma; GM-CSF receptor; Thromboembolism
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Funding
- Swiss National Science Foundation [310030_129640]
- Allergie-Stiftung Ulrich Muller-Gierok, Bern, Switzerland
- Swiss National Science Foundation (SNF) [310030_129640] Funding Source: Swiss National Science Foundation (SNF)
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In contrast to leukocytosis, paraneoplastic hypereosinophilia is uncommon in lung cancer. We present a patient with large-cell carcinoma of the lung, in which cancer cells generate large amounts of GM-CSF leading to a leukemoid reaction with prominent hypereosinophilia and potentially involved in autocrine tumor stimulation. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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