Journal
LUNG CANCER
Volume 71, Issue 2, Pages 241-243Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.lungcan.2010.11.014
Keywords
Non-small cell lung cancer; EGER mutations; EML4-ALK; Erlotinib
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The fusion gene EML4-ALK (echinoderm microtubule-associated protein-like 4 gene and the anaplastic lymphoma kinase gene) was recently identified as a novel genetic alteration in non-small cell lung cancer (NSCLC). EML4-ALK translocations correlate with specific clinical and pathological features, in particular lack of EGFR and K-ras mutations, and may be associated with resistance to EGFR tyrosine-kinase inhibitors (TKIs). Here, we report a case of a patient with a concomitant EGFR mutation and ALK translocation resistant to erlotinib. Considering this report, ALK status should be investigated in unexplained cases of EGFR-TKI-resistance of EGFR mutated NSCLCs. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
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