Journal
LUNG CANCER
Volume 69, Issue 3, Pages 341-347Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.lungcan.2009.12.007
Keywords
Lung cancer; MMP-1; Enzyme-linked immunosorbance assay; Immunohistochemical staining; Prognosis; Survival
Categories
Funding
- Chinese State Key Projects for Basic Research [2004CB518707]
- Sci-Tech Development Program of Beijing [BMSTC D0905001040731]
- National Key Technologies RD Program [2006AA02A401]
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Matrix metalloproteinase-1 (MMP-1) participates in a variety of physiological and pathological processes. We previously found that MMP-1 was one of the lung cancer-related proteins detectable in peripheral blood. To validate our preliminary observations and explore the clinical significance of MMP-1 for lung cancer further, we carried out the present study. The concentrations of MMP-1 in circulating plasma specimens of 170 lung cancer patients and 70 healthy individuals were measured by an enzyme-linked immunosorbance assay. The expression status of the MMP-1 in archival tissue samples from 122 lung cancer patients was examined by immunohistochemical analysis. The correlation between the MMP-1 levels and prognosis of the lung cancer patients was then assessed statistically. Protein levels of MMP-1 were considerably raised in the plasma from lung cancer patients relative to those in healthy controls. The high plasma MMP-1 levels were associated with advanced-stage of the disease and significantly lower overall survival rate of the patients. Coincidently, MMP-1 protein extraordinarily overexpressed in the tumour tissues of lung cancer; and the up-regulated MMP-1 was associated with the progression (including tumour size, staging and lymphatic invasion), especially with decreased survival rate of the patients. Statistic analysis revealed that MMP-1 protein levels had an independent influence on survival. MMP-1 levels were elevated in both tumour tissue and blood; the latter may serve as an independent predictor for survival of lung cancer patients. MMP-1 protein levels in plasma/serum thus represent a potential and clinically relevant biomarker for the prognosis of patients with lung cancers. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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