Journal
LUNG CANCER
Volume 65, Issue 1, Pages 123-125Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.lungcan.2009.01.019
Keywords
SCLC; Circulating tumor cells; Diagnosis
Categories
Funding
- Associazione Italiana per la Ricerca sul Cancro (AIRC)
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A 71-year-old patient with a pulmonary lesion was diagnosed with a low-grade neuroendocrine tumor following examination of a fine needle aspiration biopsy. Analysis of a peripheral blood sample with the CellSearch (TM) system revealed the presence of putative circulating tumor cells (CTC) that were positive for EpCAM and cytokeratin (CK) expression. Since EpCAM is not usually expressed in neuroendocrine tumors, we performed a biopsy of liver metastases. Morphological and immunophenotypical characterization revealed that the patient had an EpCAM and CK positive small-cell lung cancer (SCLC). By using the CellSearch (TM) apparatus, EpCAM/CK positive CTC were detected in peripheral blood samples from 3 out of 4 additional SCLC patients. This study is the first to demonstrate that CTC can be identified in SCLC patients by using the CellSearch (TM) System. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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