Journal
LUNG CANCER
Volume 64, Issue 1, Pages 28-33Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.lungcan.2008.07.013
Keywords
Therapeutic antibodies; Extra-domain B of fibronectin; Extra-domain A1 of tenascin-C; Non-small cell lung cancer; Mesothelioma; Tumor-targeting
Categories
Funding
- Swiss National Science Foundation
- Gebert-Ruf Foundation
- Schweizerische Krebsliga
- ETH Zurich
- European Union
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The antibody-mediated targeted delivery of therapeutics to tumor sites is an attractive avenue for combating cancer while sparing normal tissues. Indeed, five derivatives of the human monoclonal antibodies L19 and F16, specific to splice isoforms of fibronectin and tenascin-C, are currently being investigated in clinical trials in patients with malignancies. Until now, a comparative immunohistochemical analysis of these antibodies, which recognize components of the modified extracellular matrix, was missing. Here, we report that the majority of NSCLC and mesothelioma specimens are stained with both antibodies in the stroma, while non-tumoral lung and mesothelium samples rarely exhibit reactivity with either L19 or F16. In our analysis, the anti-tenascin F16 antibody was found to generally exhibit a stronger staining of desmoplastic stroma Surrounding tumor. This superior performance was found to be particularly striking in the case of low-grade non-small cell lung cancer. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
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