Journal
LIVER TRANSPLANTATION
Volume 17, Issue 7, Pages 789-797Publisher
WILEY
DOI: 10.1002/lt.22288
Keywords
-
Categories
Funding
- National Institutes of Health through the National Institute of Diabetes and Digestive and Kidney Diseases [U01-DK62536, U01-DK62444, U01-DK62467, U01-DK62483, U01-DK62484, U01-DK62494, U01-DK62496, U01-DK62498, U01-DK62505, U01-DK62531]
- American Society of Transplant Surgeons
- US Department of Health and Human Services through the Health Resources and Services Administration
- Columbia University Health Sciences, New York, NY [DK62483]
- Northwestern University, Chicago, IL [DK62467]
- University of Pennsylvania Health System, Philadelphia, PA [DK62494]
- University of Colorado Health Sciences Center, Denver, CO [DK62536]
- University of California Los Angeles, Los Angeles, CA [DK62496]
- University of California San Francisco, San Francisco, CA [DK62444]
- University of Michigan Medical Center, Ann Arbor, MI [DK62498]
- University of Michigan Medical Center, Ann Arbor, MI (University of North Carolina, Chapel Hill, NC) [DK62505]
- University of Virginia [DK62484]
- Medical College of Virginia Hospitals, Virginia Commonwealth University, Richmond, VA [DK62531]
- Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD [DK62498]
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The study objectives were to determine whether the findings of the Adult-to-Adult Living Donor Liver Transplantation Cohort Study (A2ALL) reflect the U. S. national experience and to define risk factors for patient mortality and graft loss in living donor liver transplantation (LDLT). A2ALL previously identified risk factors for mortality after LDLT, which included early center experience, older recipient age, and longer cold ischemia time. LDLT procedures at 9 A2ALL centers (n = 702) and 67 non-A2ALL centers (n 1664) from January 1998 through December 2007 in the Scientific Registry of Transplant Recipients database were analyzed. Potential predictors of time from transplantation to death or graft failure were tested using Cox regression. No significant difference in overall mortality between A2ALL and non-A2ALL centers was found. Higher hazard ratios (HRs) were associated with donor age (HR 1.13 per 10 years, P = 0.0002), recipient age (HR = 1.20 per 10 years, P = 0.0003), serum creatinine levels (HR = 1.52 per loge unit increase, P < 0.0001), hepatocellular carcinoma (HR 2.12, P<0.0001) or hepatitis C virus (HR = 1.18, P = 0.026), intensive care unit stay (HR = 2.52, P<0.0001) or hospitalization (HR = 1.62, P < 0.0001) versus home, earlier center experience (LDLT case number 15: HR = 1.61, P < 0.0001, and a cold ischemia time >4.5 hours (HR = 1.79, P = 0.0006). Except for center experience, risk factor effects between A2ALL and non-A2ALL centers were not significantly different. Variables associated with graft loss were identified and showed similar trends. In conclusion, mortality and graft loss risk factors were similar in A2ALL and non-A2ALL centers. These analyses demonstrate that findings from the A2ALL consortium are relevant to other centers in the U. S. performing LDLT, and conclusions and recommendations from A2ALL may help to guide clinical decision making. Liver Transpl 17:789-797, 2011. (C) 2011 AASLD.
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