Journal
LIVER INTERNATIONAL
Volume 35, Issue 3, Pages 1024-1035Publisher
WILEY-BLACKWELL
DOI: 10.1111/liv.12563
Keywords
cholangiolocellular carcinoma; classical type; combined hepatocellular and cholangiocarcinoma; subtypes with stem-cell features
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Funding
- Ministry of Education, Culture, Sports and Science and Technology of Japan [24590409]
- Grants-in-Aid for Scientific Research [24590409] Funding Source: KAKEN
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Backgrounds & AimsCombined hepatocellular-cholangiocarcinoma (cHC-CC), a malignant liver tumour with poor prognosis, is composed of hepatocellular carcinoma (HCC), cholangiocarcinoma (CC) and diverse components with intermediate features between HCC and CC, which correspond to hepatic progenitor cells. According to the WHO classification 2010, we surveyed the prevalence and clinicopathological significance of each subtype with stem-cell features [SC subtype; typical subtype (TS), intermediate cell subtype (INT) and cholangiolocellular type (CLC)] in cHC-CC and HCC. MethodsSixty-two patients with cHC-CC (19 women and 43 men) and 26 patients with HCC (all men) were examined. The prevalence of each component was histologically assessed with assistance of mucin and immunohistochemical stainings. ResultsSC subtypes were observed in all cHC-CCs in various amount and combination. The prevalence of each SC subtype in cHC-CC was as follows: TS, 10 (16.1%); INT, 53 (83.9%) and CLC, 44 (71.0%). The proportion of INT was significantly correlated with gender (female-dominant) (P<0.05), tumour size (P<0.05), histological grading of HCC (P<0.01) and inversely correlated with the degree of stromal fibrosis (P<0.05). The proportion of CLC was significantly correlated with the degree of fibrosis (P<0.01) and inflammation (P<0.01), and inversely correlated with tumour size (P<0.01) and histological grading of HCC (P<0.05). The proportion of TS was significantly inversely correlated with the degree of inflammation (P<0.01). Histological diversity score was significantly correlated with vascular invasion and the positivity for -foetoprotein. ConclusionThe proportion of each SC subtype was significantly associated with certain clinicopathological factors, suggesting different properties of each SC subtypes.
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