Journal
LIVER INTERNATIONAL
Volume 32, Issue 4, Pages 644-655Publisher
WILEY
DOI: 10.1111/j.1478-3231.2011.02675.x
Keywords
hepatitis B viruses; hepatocellular carcinoma; prognosis; regulatory T cells
Categories
Funding
- Tianjin Science and Technology commission
- key project [05YFSZSF02500]
- Tianjin Health Bureau [05KYZ13]
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Background: Recent studies have focused on regulatory T cells (Tregs) in chronic hepatitis B (CHB) and hepatocellular carcinoma (HCC) and they were also conducted independently of each other. Aims: This study tried to characterize Tregs in blood and tumour infiltration, and to explore the correlations between Tregs and the context of chronic hepatitis B in HCC patients. Methods: The liver-resident Tregs and CD8 + T cells on core biopsy were investigated using immunohistochemistry staining in individuals (n = 209) with CHB (n = 47), HCC (n = 137) or healthy controls (n = 25). Circulating Tregs were detected in the above patients with CHB (n = 27) or HCC (n = 101) by flow cytometry. Results: The number of tumour-infiltrating and circulating FoxP3 + Tregs was significantly high in patients with CHB (P < 0.001). However, there were fewer intratumoural Tregs in patients with advanced HCC than those in patients with early stage HCC (P = 0.043); In contrast, the circulating Tregs frequency increased during the progression of HCC (P = 0.024). Increased tumour-infiltrating and circulating FoxP3 + Tregs were associated with poor overall survival (P = 0.041, 0.002 respectively) and a shorter time to recurrence (P = 0.049, 0.002 respectively) in patients with early stage HCC. Tumour-infiltrating Foxp3 + Tregs were related to chronic hepatitis B natural history in HCC (P = 0.012). Neither tumour-infiltrating CD8 + T cells nor balance of intratumoural Tregs and CD8 + T cells correlated with prognosis of HCC. Conclusions: Increased Foxp3 + Tregs may represent a prognostic predictor in patients with early stage HCC. The CHB natural history influenced density of tumour-infiltrating Tregs in hepatocellular carcinoma patients with chronic hepatitis B viruses infection.
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