Journal
LIPIDS IN HEALTH AND DISEASE
Volume 11, Issue -, Pages -Publisher
BIOMED CENTRAL LTD
DOI: 10.1186/1476-511X-11-52
Keywords
beta-cryptoxanthin supplementation; Serum HMW-adiponectin; Serum PAI-1; Intervention study; Satsuma mandarin
Funding
- Research and Development Program for New Bio-industry initiatives of the Bio-oriented Technology Research Advancement Institution, Japan
- National Agriculture and Bio-oriented Research Organization (Bio-oriented Technology Research Advancement Institution), Japan
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Background: Serum beta-cryptoxanthin levels are lower in overweight subjects than in normal subjects. Abnormalities of adipocytokine profiles in obesity subjects have been reported. There are several reports that serum beta-cryptoxanthin levels in them were relatively lower than normal subjects. Objective: We hypothesize that supplementation of highly concentrated beta-cryptoxanthin improves serum adipocytokine profiles in obese subjects. This study tested the association between beta-cryptoxanthin intake and serum adipocytokine levels. Methods: An intervention study consisted of a 3-week long before-and-after controlled trial, where beta-cryptoxanthin (4.7 mg/day) was given to 17 moderately obese postmenopausal women. Results: The results indicated no significant changes in body weight or body mass index (BMI). Serum beta-cryptoxanthin levels increased significantly by 4-fold. Serum high molecular weight (HMW)-adiponectin levels increased significantly, while serum plasminogen activator inhibitor (PAI)-1 levels decreased. Conclusions: We concluded that increasing the intake of beta-cryptoxanthin to approximately 4 mg per day for 3 weeks may have beneficial effects on the serum adipocytokine status and consequently alleviate progression of metabolic syndrome.
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