Journal
LIPIDS
Volume 46, Issue 1, Pages 81-85Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s11745-010-3489-x
Keywords
Gorgonian; Dichotella gemmacea; Eicosanoid; Dichotellate A; Dichotellate B
Funding
- National Natural Science Foundation of China [40976077, 30901879, 40776073]
- Ministry of Education of China [20090132110002]
- Ministry of Science and Technology of China [2007FY210500]
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Two new eicosanoids with a unique isovalerianic acid ester group at C-12, named dichotellates A (1) and B (2), were isolated from the gorgonian Dichotella gemmacea collected from the South China Sea using bioassay-guided fractionation. Their structures were established on the basis of extensive spectroscopic analysis including one-dimensional (1D) and two-dimensional (2D) NMR as well as high-resolution ESI-MS experiments. These two compounds were evaluated for their lethal activity toward brine shrimp Artemia salina and both showed weak activity.
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