Journal
LIPIDS
Volume 43, Issue 12, Pages 1095-1107Publisher
WILEY
DOI: 10.1007/s11745-008-3261-7
Keywords
Deoxyxylulose phosphate; Dimethylallyl diphosphate; Isopentenyl diphosphate; Isoprenoid biosynthesis; Methylerythritol phosphate; Mevalonate
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Investigations on the biosynthesis of bacterial triterpenoids of the hopane series led to the unexpected discovery of an alternative mevalonate independent pathway for the formation of isoprene units. Methylerythritol phosphate, already presenting the C-5 branched isoprene skeleton, is the key intermediate. This pathway was independently characterized in ginkgo embryos for the formation of diterpenoids. It is present in most bacteria and in the plastids of all organisms belonging to phototrophic phyla. The key steps of the discovery and elucidation of this metabolic route are presented in this review.
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