Journal
LIPIDS
Volume 43, Issue 11, Pages 1085-1089Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s11745-008-3232-z
Keywords
Fish oil; Compliance; Omega-3 fatty acids; omega 3 Polyunsaturated fatty acids; Elderly; Arachidonic acid; Docosahexaenoic acid; Eicosapentaenoic acid
Funding
- Canadian Institutes for Health Research
- Natural Sciences and Engineering Research Council of Canada
- Canada Research Chairs
- Canadian Foundation for Innovation
- FORMSAV
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Little information is available concerning whether incorporation of dietary omega-3 fatty acids into plasma lipids changes during healthy aging. Elderly (74 +/- 4 years old) and young (24 +/- 2 years old) adults were given a fish oil supplement for 3 weeks that provided 680 mg/day of docosahexaenoic acid and 320 mg/day of eicosapentaenoic acid, followed by a 2 week wash-out period. Compliance was monitored by spiking the capsules with carbon-13 glucose, the excretion of which was measured in breath CO(2). In response to the supplement, plasma docosahexaenoic acid rose 42% more in the elderly but eicosapentaenoic responded similarly in both groups. Despite raising docosahexaenoic acid intake by five to tenfold, the supplement did not raise plasma free docosahexaenoic acid (% or mg/dL) in either group. We conclude that healthy aging is accompanied by subtle but significant changes in DHA incorporation into plasma lipids.
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