Journal
LIFETIME DATA ANALYSIS
Volume 15, Issue 4, Pages 468-492Publisher
SPRINGER
DOI: 10.1007/s10985-009-9134-4
Keywords
Censoring; Clinical trials; Ethical design; Optimal design; Survival data; Two-stage designs
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A randomized two-stage adaptive Bayesian design is proposed and studied for allocation and comparison in a phase III clinical trial with survival time as treatment response. Several exact and limiting properties of the design and the follow-up inference are studied, both numerically and theoretically, and are compared with a single-stage randomized procedure. The applicability of the proposed methodology is illustrated by using some real data.
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