Journal
LIFE SCIENCES
Volume 209, Issue -, Pages 383-387Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.lfs.2018.08.038
Keywords
Systemic lupus erythematosus; Glucocorticoid resistance; Glucocorticoid sensitivity; Molecular mechanisms
Funding
- National Natural Science Foundation of China [81673724]
- Chongqing Science and Technology Commission [cstc2013jcsf10012, cstc2015shmszx120105, cstc2014jcyja10025]
- Chongqing Municipal Health and Family Planning Commission of China [ZY20132154]
Ask authors/readers for more resources
The treatment of systemic lupus erythematosus (SLE) with glucocorticoids (GCs) is quite effective; however, GC resistance or insensitivity is a major barrier to the treatment of SLE. Therefore, it is necessary to identify the underlying mechanisms that lead to GC resistance. Much evidence shows that the mechanism of GC resistance is very complicated. GC receptor is involved in the main mechanism of GC resistance and was illustrated by a lot of literature. Therefore, this paper focuses on the GC resistance mechanisms of non-glucocorticoids receptor, including P-gp, MIF, TLR9, and Th17 cells. These molecular mechanisms may help diagnose GC resistance and provide an alternative treatment strategy to reverse GC resistance by blocking the underlying mechanisms.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available