Journal
LIFE SCIENCES
Volume 89, Issue 15-16, Pages 545-554Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.lfs.2011.05.003
Keywords
Natural compounds; Wnt signaling pathway; Cancer; Isoquercitrin; Polyphenols; Small molecules
Funding
- FAPERJ
- CNPq
- CAPES
- National Institute of Technology for Translational Neuroscience
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Flavonoids are polyphenolic compounds found throughout the plant kingdom. They occur in every organ but are usually concentrated in leaves and flowers. During the last two decades, in vitro and in vivo studies demonstrated that flavonoids have inhibitory effects on human diseases through targeting of multiple cellular signaling components. Wnt/beta-catenin signaling regulates proliferation, differentiation and fate specification in developmental stages and controls tissue homeostasis in adult life. For these reasons, this pathway has received great attention in the last years as potential pathway involved in distinct Human pathologies. In this review we discuss the emerging potential mechanisms for flavonoids on Wnt/beta-catenin signaling in cancer and possible investigation strategies to understand flavonoids mode of action on this signaling pathway. (C) 2011 Elsevier Inc. All rights reserved.
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