Journal
LIFE SCIENCES
Volume 89, Issue 15-16, Pages 570-576Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.lfs.2011.05.014
Keywords
Preconditioning; N-methyl-D-aspartate; Neuroprotection; Glutamatergic excitotoxicity; Quinolinic acid; NMDA receptor
Funding
- CAPES/PRODOC
- REUNI Program scholarship
- INCT
- CNPq
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The search for novel, less invasive therapeutic strategies to treat neurodegenerative diseases has stimulated scientists to investigate the mechanisms involved in preconditioning. Preconditioning has been report to occur in many organs and tissues. In the brain, the modulation of glutamatergic transmission is an important and promising target to the use of effective neuroprotective agents. The glutamatergic excitotoxicity is a factor common to neurodegenerative diseases and acute events such as cerebral ischemia, traumatic brain injury and epilepsy. In this review we focus on the neuroprotection and preconditioning by chemical agents. Specially, chemical preconditioning models using N-methyl-D-aspartate (NMDA) pre-treatment, which has demonstrated to lead to neuroprotection against seizures and damage to neuronal tissue induced by quinolinic acid (QA). Here we attempted to gather important results obtained in the study of cellular and molecular mechanisms involved in NMDA preconditioning and neuroprotection. (C) 2011 Elsevier Inc. All rights reserved.
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