Journal
LEUKEMIA RESEARCH
Volume 38, Issue 8, Pages 913-917Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.leukres.2014.05.020
Keywords
GVHD; Hematopoietic cell transplantation; Methotrexate; MMF
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We hypothesized that in patients with early post allogeneic transplantation toxicities, the omission of the 3rd dose of methotrexate with concomitant starting of MMF would favorably affect complications. We found a higher incidence of grade 2-4 acute GVHD in patients given two doses methotrexate and MMF(n = 31) compared to those given three courses of methotrexate (n = 70) (p = .004), while grade 3-4 was similar. Other transplantation outcomes, including overall regimen-related-toxicity, were comparable. We conclude that tailoring the GVHD prophylaxis regimen may decrease the early post transplantation complications, however this come at the extent of a higher incidence of non-severe acute GVHD. (C) 2014 Elsevier Ltd. All rights reserved.
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