Journal
LEUKEMIA RESEARCH
Volume 38, Issue 2, Pages 263-266Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.leukres.2013.07.002
Keywords
Experimental inflammation model; Myeloproliferative neoplasms; NF-E2 overexpression; Chronic inflammation; Reactive oxygen species (ROS); NE-kappabeta activation; IL-1beta; IL-6; IL-8; TNF-alpha; Human inflammation model
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A novel murine model for myeloproliferative neoplasms (MPNs) generated by overexpression of the transcription factor NF-E2 has recently been described. Sustained overexpression of NF-E2 in this model induced myeloid expansion with anemia, leukocytosis and thrombocytosis. Herein, it is debated if NF-E2 overexpression also might have induced a sustained state of in vivo leukocyte and platelet activation with chronic and self-perpetuating production of inflammatory products from activated leukocytes and platelets. If so, this novel murine model also may excellently describe the deleterious impact of sustained chronic NF-E2 overexpression during uncontrolled chronic inflammation upon the hernatopoietic system - the development of clonal myeloproliferation. Accordingly, this novel murine model may also have delivered the proof of concept of chronic inflammation as a trigger and driver of clonal evolution in MPNs. (C) 2013 Elsevier Ltd. All rights reserved.
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