Journal
LEUKEMIA RESEARCH
Volume 38, Issue 4, Pages 469-474Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.leukres.2014.01.007
Keywords
Invasive fungal disease; Aspergillosis; Acute myeloid leukemia; Complete remission; Survival
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We retrospectively evaluated, in a logistic-regression-model, the role of proven/probable invasive fungal diseases (PP-IFD), occurring during first induction chemotherapy, on the achievement of complete remission (CR) and overall survival (OS) in 198 acute myeloid leukemia (AML) patients. A PP-IFD was documented in 34 (17.2%) patients. Younger age, good performance status at AML diagnosis and no development of a PP-IFD (OR 4.09, 95% Cl 1.71-9.81, p <0.0001) were independent factors associated to CR achievement. Younger age, good performance status, favorable genetic risk and no development of PP-IFD (HR 1.86, 95% Cl 1.20-2.88, p = 0.005) were independent factors associated to OS at 3 years. (C) 2014 Elsevier Ltd. All rights reserved.
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