Journal
LEUKEMIA RESEARCH
Volume 38, Issue 4, Pages 490-495Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.leukres.2014.01.014
Keywords
Myeloproliferative neoplasms; Essential thrombocythemia; Polycythemia vera; Myelofibrosis; Chronic kidney disease; Chronic inflammation; Hydroxyurea
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Background: The progression of kidney function and frequency of chronic kidney disease (CKD) in patients with the Philadelphia-negative myeloproliferative neoplasms (MPN) is unknown, although CKD is linked to increased mortality. Methods: This longitudinal retrospective study evaluates the estimated glomerular filtration rate (eGFR) in 143 MPN patients over a period of 9 years. Results: 29% of patients had CKD stage 3 or 4 at time of diagnosis. 20% of patients had a rapid annual loss of eGFR (>3 mL/min/1.73 m(2)) and eGFR was negatively correlated to monocyte and neutrophil counts. Conclusion: Kidney impairment might contribute to the increased mortality observed in MPN patients. (C) 2014 Elsevier Ltd. All rights reserved.
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