Journal
LEUKEMIA RESEARCH
Volume 37, Issue 4, Pages 392-395Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.leukres.2012.12.016
Keywords
Cause of death; Eosinophilia; Hypereosinophilic syndrome; Mortality; Hypereosinophilia
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Background: Information in the literature regarding causes of mortality in patients with hypereosinophilic syndrome (HES) is limited. Methods: This was a retrospective review of the morbidities and causes of death in HES patients at Mayo Clinic. Results: Overall, out of the 247 diagnosed HES patients, 23 died during the 19 years that this review encompassed. The cause of death was identified in 15 patients (65%): cardiac dysfunction in 5 (33%), infection in 3 (20%), unrelated malignancy in 3 (20%), thromboembolic phenomena in 2 (13%), and vascular disease in 2 (13%). Conclusion: Targeted monitoring of the at-risk end organs, combined with early treatment, may have the ability to improve survival and reduce morbidity in HES patients. (c) 2012 Elsevier Ltd. All rights reserved.
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