Journal
LEUKEMIA RESEARCH
Volume 37, Issue 4, Pages 410-415Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.leukres.2012.12.014
Keywords
Vascular endothelial growth factor; Angiopoietin-2; Progression free survival; Multiple myeloma
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Funding
- Department of Biotechnology (DBT), New Delhi, India
- Indian Council of Medical Research (ICMR), New Delhi, India
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Bone marrow neoangiogenesis plays an important role in multiple myeloma (MM) and depends on the interplay of angiogenic cytokines. We investigated the levels of angiogenic cytokines such as vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), angiopoietin (Ang)-1, Ang-2 and hypoxia inducible factor-1 alpha (HiF-1 alpha) in MM patients and their association with treatment outcome. Serum levels and mRNA expression of VEGF, Ang-2, Ang-1, bFGF and HiF-1 alpha were evaluated in 71 MM patients using enzyme-linked immunosorbent assay and reverse transcriptase polymerase chain reaction. In multivariate Cox regression analysis, serum levels of VEGF >= 756 pg/ml (HR 2.2, 95% CI 1.02-4.91; p = 0.045) and relative mRNA expression levels of Ang-2 >= 0.93 (HR 21.0, 95% CI 6.27-70.45; p < 0.001) were predictive of inferior progression free survival (PFS) and patients with concomitant increase in VEGF and Ang-2 had poor outcome compared to the rest of the patients (HR 32.6, 95% CI 7.20-148.36; p < 0.001). These results suggest that VEGF and Ang-2 act in synergy and their expression levels at presentation are predictive of PFS in MM. (c) 2012 Elsevier Ltd. All rights reserved.
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