Lack of association between TNF-α promoter polymorphisms and multiple myeloma: A meta-analysis

Results of available literatures, which concerned the association between TNF-alpha promoter -238/-308 gene polymorphisms and multiple myeloma (MM), are of great controversy. A review was performed in studies reporting on the association between them. Odds ratios (ORs) with 95% confidence interval (CI) were used to evaluate the association. The pooled ORs indicated that there was no association between TNF-alpha -238/-308 polymorphisms and MM susceptibility in overall population. Sub-group analysis also confirmed that no evidence supported the relevance of TNF-alpha promoter -238/-308 gene polymorphisms with MM. Studies with large sample size and multi-ethnics may be needed to further explore the association between them. (C) 2012 Elsevier Ltd. All rights reserved.