Journal
LEUKEMIA RESEARCH
Volume 37, Issue 9, Pages 1057-1062Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.leukres.2013.06.025
Keywords
Febrile neutropenia; PET/CT; Hematological malignancies; FDG; Invasive fungal infections
Categories
Funding
- Israeli Cancer Association
- Israeli Ministry of Health Chief Scientist award
- research grant for young investigators in Rabin Medical Center, Petah-Tikva, Israel
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We assessed the performance of PET/CT for diagnosis and management of infections in high-risk hematological cancer patients with persistent febrile neutropenia in a prospective study. F-18-FDG PET/CT with contrast-enhanced CT was performed on day 5-7 of persistent fever. Between 2008 and 2011, 91 PET/CT examinations were performed for different episodes in 79 patients, resulting in 117 diagnoses. The sensitivity of the PET/CT was 79.8% (71/89) compared to 51.7% (46/89) with chest/sinus CT alone. Specificities were 32.14% (9/28) vs. 42.85% (12/28), respectively. PET/CT resulted in a change from the pre-test diagnosis in 63/91 (69%) of episodes and in modification of patients' management in 46/91 (55%). PET/CT was beneficial in diagnosing abdominal infections. PET/CT has a potential role in the diagnostic evaluation of patients with persistent febrile neutropenia. (C) 2013 Elsevier Ltd. All rights reserved.
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