Journal
LEUKEMIA RESEARCH
Volume 37, Issue 9, Pages 1120-1124Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.leukres.2013.05.003
Keywords
JAK/STAT signaling pathway; Non-Hodgkin lymphoma; Polymorphism; Case-control study
Categories
Funding
- NIH [CA62006, CA165923, 1D43TW008323, 1D43TW007864, HD70324]
- Intramural Research Program of the National Cancer Institute
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Impaired function of Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway genes leads to immunodeficiency and various hematopoietic disorders. We evaluated the association between genetic polymorphisms (SNPs) in 12 JAK/STAT pathway genes (JAK3, STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, STAT6, SCOS1, SCOS2, SCOS3, and SCOS4) and NHL risk in a population-based case-control study of Connecticut women. We identified three SNPs in STAT3 (rs12949918 and rs6503695) and STAT4 (rs932169) associated with NHL risk after adjustment for multiple comparison. Our results suggest that genetic variation in JAK/STAT pathway genes may play a role in lymphomagenesis and warrants further investigation. (C) 2013 Elsevier Ltd. All rights reserved.
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