Journal
LEUKEMIA RESEARCH
Volume 36, Issue 3, Pages 293-298Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.leukres.2011.10.005
Keywords
MicroRNA; Pediatric acute lymphoblastic leukemia; Prognostic features
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Funding
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2009/10191-2]
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) [471129/2009-7]
- FAEPA (Brazil)
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The present study aimed to analyze the expression profile of the microRNAs previously described as associated with childhood ALL, miR-92a, miR-100, miR-125a-5p, miR-128a, miR-181b, miR-196b and let-7e, and their association with biological/prognostic features in 128 consecutive samples of childhood acute lymphoblastic leukemia (ALL) by quantitative real-time PCR. A significant association was observed between higher expression levels of miR-196b and T-ALL, miR-100 and patients with low white blood cell count at diagnosis and t(12;21) positive ALL. These findings suggest a potential activity of these microRNAs in pediatric ALL biology. (C) 2011 Elsevier Ltd. All rights reserved.
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