Journal
LEUKEMIA RESEARCH
Volume 35, Issue 6, Pages 705-711Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.leukres.2010.12.031
Keywords
CNS; ALL; Subarachnoid space; Chemotherapy; Survival
Categories
Funding
- NIH [R01 HL056888, R01 CA134573, P20 RR016440]
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CNS infiltration by leukemic cells remains a problematic disease manifestation of acute lymphoblastic leukemia (ALL). Prophylactic regimens for CNS leukemia including intrathecal chemotherapeutics have decreased CNS involvement in ALL, but are not without toxicities. Using co-culture models, we show that astrocytes, choroid plexus epithelial cells, and meningeal cells protect ALL cells from chemotherapy-induced cell death using drugs included in prophylactic regimens-cytarabine, dexamethasone, and methotrexate. Understanding how ALL cells survive in the CNS remains invaluable for designing strategies to prevent CNS leukemia and minimizing the need for treatment in this sensitive anatomical site where treatment-induced toxicity is of significant concern. (C) 2011 Elsevier Ltd. All rights reserved.
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