Journal
LEUKEMIA RESEARCH
Volume 35, Issue 10, Pages 1301-1306Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.leukres.2011.01.019
Keywords
AML; IDH1; Mutation analysis; Characterization; Fusion gene
Categories
Funding
- National Natural Science Foundation [30700419, 30971290]
- Special Scientific Fund for Public Welfare Industry (Health) [201002024]
- Tianjin Applied Fundamental Research Planning Key Project [10JCZDJC19600]
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Mutations of isocitrate dehydrogenase 1 (IDH1) have recently been reported in acute myeloid leukemia (AML). However, the characteristics of IDH1-mutated AML are still not known clearly. We analyzed 416 Chinese AML patients and found 28 patients (6.7%) carried this mutation. One homozygous IDH1 mutant in AML was found. The IDH1 mutations were associated with NPM1 mutations (P=0.043) and could coexist with recurrent transcription factor aberrations including AML1-ETO (6/50), PML-RAR alpha (3/77) and CBF beta-MYH11 (1/15). For AML with AML1-ETO fusion gene, IDH1(mut) patients may have worse disease-free survival (DFS) than IDH1(wild-type) patients. (C) 2011 Elsevier Ltd. All rights reserved.
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