Journal
LEUKEMIA RESEARCH
Volume 34, Issue 4, Pages 426-429Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.leukres.2009.09.012
Keywords
T cell acute lymphoblastic leukemia; Ikaros; Tumor suppressor; Cytoplasmic retention
Categories
Funding
- Institut National du Cancer
- Ligue contre le Cancer
- INSERM
- CNRS
- University of Strasbourg
- Association pour la Recherche sur le Cancer (ARC)
- Ligue Regionale Contre le Cancer
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The Ikaros (Ikzf1) gene, encoding a transcription regulator, is a major tumor suppressor in B-cell acute lymphoblastic leukemia (B-ALL). In the mouse, however, loss of Ikaros is primarily associated with T-ALL development. Whether Ikaros is also implicated in human T-ALL remains unclear. We studied Ikaros in 25 human T-ALL samples from diverse molecular subtypes at the mRNA, protein, sequence and genomic copy number level. We found that Ikaros was abnormal in only one sample: one allele was lost by genomic deletion, while proteins generated from the remaining allele were delocalized and concentrated at a single cytoplasmic structure. Thus, inactivation of Ikaros by deletion or mutation is rare in human T-ALL. (C) 2009 Elsevier Ltd. All rights reserved.
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