Journal
LEUKEMIA RESEARCH
Volume 34, Issue 9, Pages 1143-1150Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.leukres.2010.03.009
Keywords
Myelodysplastic syndromes; Deferasirox; Serum ferritin; Labile plasma iron; Iron chelation therapy
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Funding
- Novartis Pharma AG (Basel, Switzerland)
- Novartis
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The prospective 1-year EPIC study enrolled 341 patients with myelodysplastic syndromes (MDS); although baseline iron burden was >2500 ng/mL, similar to 50% were chelation-naive. Overall median serum ferritin decreased significantly at 1 year (p = 0.002). Decreases occurred irrespective of whether patients were chelation-naive or previously chelated; changes were dependent on dose adjustments and ongoing iron intake. Sustained reductions in labile plasma iron were observed. Discontinuation rate (48.7%) and adverse event profile were consistent with previously reported deferasirox data in MDS. Alanine aminotransferase levels decreased significantly; change correlated significantly with reduction in serum ferritin (p < 0.0001). This large dataset prospectively confirms the efficacy and well characterizes the safety profile of deferasirox in MDS. (C) 2010 Elsevier Ltd. All rights reserved.
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