Journal
LEUKEMIA RESEARCH
Volume 34, Issue 12, Pages 1566-1572Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.leukres.2010.02.021
Keywords
Myelodysplastic syndrome; Acute myeloid leukemia; Gene expression profiling; Microarray; CD34+cells
Categories
Funding
- Internal Grant Agency [NR9235, NS9634]
- Ministry of Health of the Czech Republic [MZ0UHKT2005]
Ask authors/readers for more resources
Gene expression profiles of CD34+ cells were compared between 51 MDS patients and 7 controls. The most up-regulated genes in patients included HBG2, HBG1, CYBRD1, HSPA1B, ANGPT, and MYC, while 13 genes related to B-lymphopoiesis showed down-regulation. We observed in advanced MDS patients decreased expression of genes involved in cell cycle control, DNA repair and increased expression of proto-oncogenes, angiogenic and anti-apoptic genes. The results suggest that increased cell proliferation and resistance to apoptosis together with a loss of cell cycle control, damaged DNA repair and altered immune response may play an important role in malignant clone expansion in MDS. (C) 2010 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
