Journal
LEUKEMIA RESEARCH
Volume 33, Issue 2, Pages 297-307Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.leukres.2008.08.006
Keywords
Tannic acid; Acute myeloid leukemia cells; Apoptosis; Superoxide; SOD
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Funding
- National Science Council, Taiwan [NSC96-2313-B-166-002-MY2, NSC 96-2311-B-040-005-MY2]
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Tannic acid (TA), a glucoside of gallic acid polymer, has been shown to possess anti-bacterial, anti-enzymatic, anti-tumor and astringent properties. However, the anti-cancer activity of TA in leukemia is still obscure. In this Study, we showed TA-induced apoptotic death in acute myeloid leukemia (AML) HL-60 cells via dose- and time-dependent manner as well as increase of sub-G1 fraction. chromosome condensation. and DNA fragmentation. Further analysis demonstrated the involvement of activation of caspase cascade. cleavage of poly (ADP-ribose) polymerase (PARP), disruption of mitochondrial membrane potential, and release of Cytochrome C, in TA-induced apoptosis. These effects were probably associated with the increase of intracellular Superoxide in mitochondrial signaling pathway which attributed 10 the down-regulation of superoxide dismutase (SOD). Notably, a low dose of TA is sufficient to aggravate arsenic trioxide (As2O3)-induced cytotoxicity in HL-60 cells. Altogether, this Study suggested the effects of TA to induce apoptosis in HL-60 and therapeutic potential in AML being an adjunct to As2O3. (C) 2008 Elsevier Ltd. All rights reserved.
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