Journal
LEUKEMIA RESEARCH
Volume 33, Issue 11, Pages 1539-1551Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.leukres.2009.05.013
Keywords
Leukemia; T-cells; Apoptosis; Kinases/phosphatases; Signal transduction; PEA-15; Mutation; PPX; PPP4
Categories
Funding
- Leukaemia Research Fund
- Wellcome Trust [074452]
- BBSRC (GTW)
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The control of T-cell survival is of overwhelming importance for preventing leukemia and lymphoma. The present report demonstrates that the serine/threonine protein phosphatase PP4 regulates the survival of both leukemic T-cells and untransformed human peripheral blood T-cells, particularly after treatment with anti-leukemic drugs and other cytotoxic stimuli. PP4-induced apoptosis is mediated, at least in part, through de-phosphorylation of apoptosis regulator PEA-15, previously implicated in the control of leukemic cell survival. PP4 activity significantly affects the mutation rate in leukemic T-cells, indicating that PP4 dysfunction may be important in the development and progression of leukemia. (C) 2009 Elsevier Ltd. All rights reserved.
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